Saxon,
Had a 1951 OP, out of time when I got it.
I had a slightly newer OP, out of time when I got it.
The Python I bought brand new in about 94 was out of time on two chambers.
The unfired 1966 Trooper .357 is out on two chambers. (Will be going back to Colt later this year.)
That's four of mine to counter four of yours. New, old, you got some that stayed in time, I got some that didn't.
Not all of the old Vs developed timing issues, but they did if you shot 'em enough, and the hotter loads placed more strain on the weakest part in the action- the hand.
If you check with knowledgeable gunsmiths that have been in the biz for 30+ years & ask which action among the three, S&W, Ruger, or the older Colts, goes out of time the most with roughly comparable use, they'll tell you Colt.
I can take a new Ruger GP & my Trooper, shoot 10,000 full-bore .357 rounds through them both, and I'll tell you the Colt will not hold up to it the way the Ruger will.
The Ruger will still be going strong long after the Colt is reduced to a wobbly out-of-time shadow of its former self.
Regardless of how much the relatively few fans on a gun forum like those Colts, they're not coming back & the reasons have been given.
Denis