Ed; I'm a little confused. 1st; I love the 45acp. It is by far my favorite handgun caliber. The slowness and mass make for a very easy to shoot weapon that is very effective on human targets. It is by far my favorite. But I don't understand how you can call the 357 magnum cartridge intermediate. Intermediate implies that it is in the "Middle" some place between others. With the exception of HUNTING handguns such as the 41mag, 44mag, 460, 480, 500 and others I have missed; there isn't one caliber handgun from 22lr all the way to 45acp that can reach the velocity and energy of the 357 magnum. Even factory loads can easily take the 357 magnum to 1400 fps and 600 ft/lbs.
And the other advantages of the 357 magnum is that it can go as low as a 70 grain bullet or up to 200 grains. It can be used on practically anything imaginable. It can be found and fired in revolvers, semi-autos, and rifles. Not even considering it's 38 special sister that can be fired in the same weapon; the 357 in it's own right, can be loaded with the similar weight bullets, velocity, and energy of a 9mm, through the 40sw, 10mm, and 45acp. The only calibers the 357 magnum can't reach is the smaller calibers of the 25, 32, and 380 auto; and the faster hunting rounds of the 41 mag, 44 mag, 460, 480, 500 and similar. And this isn't even considering some of the specialty ammo out there that can push a 125 grain bullet 1700 fps and 800 ft/lbs. Personally; I believe the 357 magnum to be the best caliber on the market. It can do ANYTHING that the 9mm through the 45acp and everything in between. I personally us 158 grain Hydra-shoks which is about 300 fps and 100 ft/lbs stronger than a 45acp.
But even though the 45acp is my favorite for self/home defense; there is no way I could even consider the 357 magnum as being intermediate. It is the most versatile caliber there is. It is the most powerful of traditionally accepted self defense hand guns; yet capable of being as soft as a 9mm. The only disadvantage some people may have with it is that it generally is used in a revolver, and therefor limited to 6 rounds. But for self/home defense purposes, that is generally more than enough. But except for that for some people, the 357 magnum is still the BEST overall caliber in any of the handgun ranges. Especially for self/home defense.