Now if you are done delving into my confrontational attitude instead of just answering questions, I leave you to it.
I did answer your questions, but let me go a little further with my answer. The OP wanted ideas on the best general HG caliber, including, but not limited to, hunting. I think that the .357 fulfills thats need because, generally, it does a lot of things very well, and it does others well enough. Had he asked for the best bear gun, my answer would have been different, but he asked for the best general cartridge, not the best hunting cartridge. That being said, the .357 is plenty capable as a deer round, particularly when you consider that handgun hunting requires closer ranges than does rifle hunting. A 165 grain bullet that delivers 518ft/lbs at 50 yards is enough for a deer. Bowhunters regularly whack monster deer with considerably less. It is about 200 or so ft/lbs less than a .44, but it is enough.
Now then, let me answer this statement:
you theorize because you are enamored with a cartridge that you shoot well. I responded from personal experience. And I can tell you this much... just because you shoot a particular caliber well does not make it suitable for shooting game.
I do not theorize that the .357 is suitable for shooting game, I know it is, at least if you use some common sense. It clearly is not suitable for moose or bear, although I would add that a perfectly placed shot on either makes that argument somewhat null and void. I don't have the hunting experience to back that claim up because I hunt with a rifle, which, I would add, is the far more efficient platform for hunting in terms of terminal effect. The fastest .44 is still considerably slower than the slowest .270, after all. I have shot other calibers, and my experience tells me that the .357 is the easiest "big" caliber revolver to shoot. I would also add that I don't disagree with your comment on the .22 (or .32, I guess), as I go out fishing with a .22 far more often than I do with a .357. When I am deep in the woods, however, the .357 is my choice.
Sorry if I didn't understand your sense of humor. It is sometimes hard to tell when someone is being sarcastic on a forum, and I have had people misunderstand me before. It just seemed like it was unnecessarily hostile, is all. If thats not how you meant it, then I am sorry I took it that way.